Mikey’s back and about to face his greatest challenge… his new sister.
Mollie and James are together and raising a family, which now consists of an older Mikey and his baby sister, Julie. Tension between the siblings arises, and as well with Mollie and James when Mollie's brother Stuart moves in. Mikey is also learning how to use the toilet for the first time.
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John Travolta
James
Kirstie Alley
Mollie
Olympia Dukakis
Rosie
Elias Koteas
Stuart
Twink Caplan
Rona
Bruce Willis
Mikey (voice)
Roseanne Barr
Julie (voice)
Damon Wayans
Eddie (voice)
Gilbert Gottfried
Joey
Mel Brooks
Mr. Toilet Man (voice)
Lorne Sussman
Mikey
Megan Milner
Julie (1 year)
Georgia Keithley
Julie (4 months)
Nikki Graham
Julie (newborn)
Danny Pringle
Eddie
